当肾功能损害时,某些抗菌素或其代谢产物可发生积聚而导致毒性反应的发生,对于肾脏有较大毒性的抗菌素或抗菌素主要经肾排泄时,此种情况尤应引起注意。近年来由于慢性肾脏疾病的处理方面已取得不少进展(主要是长期透析术的应用),使临床医师面临更多不同程度肾功能损害的患者。此类患者对于各种感染特别敏感,经常需要接受抗菌素治疗。此外,在严重感染引起中毒性休克时,原来功能良好的肾脏亦可能迅速出现损害,甚至发展为 When renal dysfunction, some antibiotics or their metabolites may accumulate and lead to the occurrence of toxic reactions, the more toxic to the kidneys of the main antibiotic or antibiotic excretion by the kidneys, this situation should pay particular attention. In recent years, considerable progress has been made in the treatment of chronic kidney disease (mainly the application of long-term hemodialysis), so that clinicians face more patients with varying degrees of renal dysfunction. Such patients are particularly sensitive to various infections and often require antibiotic treatment. In addition, when a serious infection causes toxic shock, the well-functioning kidneys may also rapidly develop damage, even developing into