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对４５例有更年期症状的妇女进行雌激素替代治疗。选用尼尔雌醇，每２周服药２ｍｇ，对控制更年期症状有显著疗效。服药３个月后，９１％的病人症状明显减轻，不同的症状均有不同程度的改善，尤对潮热出汗、眩晕、疲乏、急躁、阴道干燥等症状效果显著。服药３个月后Ｋｕｐｐｅｒｍａｎ评分下降５８．６％，无明显药物副反应。服药３个月加用安宫黄体酮每日１０ｍｇ，共７天。取子宫内膜未见癌变，亦未发现其它肿瘤，为我国目前雌激素替代治疗的首选药物。
Forty-five women with menopausal symptoms were treated with estrogen replacement therapy. Use nilestriol, taking 2mg every 2 weeks, have a significant effect on the control of menopausal symptoms. After taking medicine for 3 months, 91% of the patients had obvious symptoms relieved and different symptoms improved in different degrees, especially for the symptoms of hot flashes sweating, dizziness, fatigue, irritability and vaginal dryness. Kupperman’s score decreased 58.6% 3 months after taking the medication, no obvious side effects of the drug. Medication plus 3 months progesterone progesterone daily 10mg, a total of 7 days. Take no endometrial cancer, also found no other tumor, estrogen replacement therapy for the current drug of choice.