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目的观察血管紧张素受体拮抗剂(ARB)治疗顽固性高血压的临床疗效。方法选择2011年1月—2013年1月我院心内科收治的顽固性高血压患者76例,将其随机分成治疗组和对照组,各38例。两组患者均给予基础治疗,在此基础上,治疗组采用ARB——厄贝沙坦进行治疗,对照组采用依那普利进行治疗,均治疗1个月,并比较两组患者临床疗效。结果治疗组总有效率为97.4%(37/38),高于对照组的89.5%(34/38)(P<0.05)。治疗前两组患者收缩压和舒张压比较,差异均无统计学意义(P>0.05);治疗后治疗组收缩压和舒张压均低于对照组(P<0.05)。结论 ARB治疗顽固性高血压疗效显著,可以有效降低血压。
Objective To observe the clinical effect of angiotensin receptor blocker (ARB) on refractory hypertension. Methods From January 2011 to January 2013, 76 patients with refractory hypertension admitted to our hospital were randomly divided into treatment group and control group, with 38 cases in each group. Both groups were given basic treatment. On this basis, the treatment group was treated with ARB-irbesartan, the control group was treated with enalapril for 1 month, and the clinical efficacy was compared between the two groups. Results The total effective rate in the treatment group was 97.4% (37/38), which was higher than that in the control group (89.5%, 34/38) (P <0.05). Before treatment, the systolic and diastolic blood pressures in the two groups were not significantly different (P> 0.05). After treatment, the systolic and diastolic blood pressure were lower in the treatment group than those in the control group (P <0.05). Conclusion ARB treatment of refractory hypertension significant effect, can effectively reduce blood pressure.