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目的探讨乙型肝炎免疫球蛋白(HBIG)联合乙型肝炎疫苗(HBVac)阻断乙型肝炎病毒(HBV)母婴传播的效果。方法共110例,随机分为观察组55例和对照组55例,对照组患者给予HBVac注射,观察组患者给予HBVac联合HBIG注射。结果观察组新生儿HBs Ag阳性率为9.1%,HBs Ab阳性率为90.9%,对照组新生儿HBs Ag阳性率为92.7%,HBs Ab阳性率为7.3%,观察组明显优于对照组(P<0.01)。结论 HBIG联合HBVac是阻断HBV母婴传播的有效方法。
Objective To investigate the effect of hepatitis B immunoglobulin (HBIG) combined with hepatitis B vaccine (HBVac) on the mother-infant transmission of hepatitis B virus (HBV). Methods A total of 110 patients were randomly divided into observation group 55 cases and control group 55 cases, control group received HBVac injection, observation group received HBVac combined with HBIG injection. Results The positive rate of HBsAg in neonates was 9.1% and the positive rate of HBs Ab in observation group was 90.9%. The positive rate of HBsAg in neonates was 92.7% and the positive rate of HBs Ab in observation group was 7.3% <0.01). Conclusion HBIG combined with HBVac is an effective way to block the transmission of HBV from mother to infant.