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流行病学调查认为非甾体类抗炎药可以降低结直肠癌死亡率,主要作用靶点是环氧合酶-2(COX-2)。COX-2作为前列腺素生物合成的限速酶,可能在结直肠肿瘤发生和发展中起到重要作用。本研究应用实时荧光定量RT-PCR方法定量分析了结直肠正常黏膜、腺瘤、癌和转移组织中COX-2mRNA的表达
Epidemiological survey that non-steroidal anti-inflammatory drugs can reduce colorectal cancer mortality, the main target is cyclooxygenase-2 (COX-2). As a rate-limiting enzyme in prostaglandin biosynthesis, COX-2 may play an important role in the development and progression of colorectal tumors. In this study, the expression of COX-2 mRNA in normal colorectal mucosa, adenoma, carcinoma and metastasis was quantitatively analyzed by real-time fluorescence quantitative RT-PCR