Using NCEP short range ensemble forecast (SREF) system, demonstrated two fundamental on-going evolu-tions in numerical weather prediction (NWP) are through ensemble methodology. One evolution is the shift from traditional single-value deterministic forecast to flow-dependent (not statistical) probabilistic forecast to address forecast uncertainty. Another is from a one-way observation-prediction system shifting to an in-teractive two-way observation-prediction system to increase predictability of a weather system. In the first part, how ensemble spread from NCEP SREF predicting ensemble-mean forecast error was evaluated over a period of about a month. The result shows that the current capability of predicting forecast error by the 21-member NCEP SREF has reached to a similar or even higher level than that of current state-of-the-art NWP models in predicting precipitation, e.g., the spatial correlation between ensemble spread and absolute fore-cast error has reached 0.5 or higher at 87 h (3.5 d) lead time on average for some meteorological variables. This demonstrates that the current operational ensemble system has already had preliminary capability of predicting the forecast error with usable skill, which is a remarkable achievement as of today. Given the good spread-skill relation, the probability derived from the ensemble was also statistically reliable, which is the most important feature a useful probabilistic forecast should have. The second part of this research tested an ensemble-based interactive targeting (E-BIT) method. Unlike other mathematically-calculated objec-tive approaches, this method is subjective or human interactive based on information from an ensemble of forecasts. A numerical simulation study was performed to eight real atmospheric cases with a 10-member, bred vector-based mesoscale ensemble using the NCEP regional spectral model (RSM, a sub-component of NCEP SREF) to prove the concept of this E-BIT method. The method seems to work most effective for basic atmospheric state variables, moderately effective for convective instabilities and least effective for precip-itations. Precipitation is a complex result of many factors and, therefore, a more challenging field to be improved by targeted observation.