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目的研究血管紧张素转换酶(ACE)基因多态性与纤溶系统之间的关系。方法选择冠心病、高血压患者126例和健康对照者66例,分别检测ACE基因及多态性,测定血浆中D-二聚体(dD)、凝血酶原时间(PT)、纤维蛋白原(Fg)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)各值。结果①疾病组dD、Fg、APTT水平明显高于对照组(P<0.05),而PT、TT水平明显低于对照组(P<0.05)。②基因DD型疾病组dD、Fg水平明显高于ID、Ⅱ型组(P<0.05),而PT、TT、APTT水平明显低于ID、Ⅱ型组(P<0.05),差异有统计学意义。③ACE基因多态性与dD、Fg浓度间显著正相关(r值分别为0.671、0.702,P<0.01);与PT、TT、APTT浓度间存在显著负相关(r=-0.648、-0.683、-0.653,P<0.001)。结论 ACE基因DD型和D等位基因与纤溶系统有关,I等位基因则无关。
Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and fibrinolytic system. Methods A total of 126 patients with coronary heart disease and hypertension and 66 healthy controls were enrolled in this study. ACE gene and polymorphism were detected respectively. Plasma d-dimer, prothrombin time (PT), fibrinogen Fg), thrombin time (TT), activated partial thromboplastin time (APTT) values. Results ① The levels of dD, Fg and APTT in the disease group were significantly higher than those in the control group (P <0.05), while the levels of PT and TT in the disease group were significantly lower than those in the control group (P <0.05). ② The levels of dD and Fg in DD group were significantly higher than those in ID group and Ⅱ group (P <0.05), while the levels of PT, TT and APTT in ID group were significantly lower than those in ID group and Ⅱ group (P <0.05) . ③ There was a significant positive correlation between ACE gene polymorphism and the concentrations of dD and Fg (r = 0.671, 0.702, respectively, P <0.01), but negatively correlated with the concentrations of PT, TT and APTT 0.653, P <0.001). Conclusion The ACE genotype DD and D allele are related to fibrinolytic system, while the I allele is unrelated.