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近些年来研究表明 ,质粒介导的AmpCβ -内酰胺酶主要由肠杆菌科细菌产生 ,具有比ESBLs酶更广的水解底物谱 ,能有效水解三代头孢菌素类、单环类及头霉素类抗生素 ,且不受酶抑制剂所抑制。携带编码ampC酶基因质粒快速复制和可转移性的特点 ,导致耐药性广泛传播 ,给临床治疗带来极大困难。本文就质粒介导的AmpCβ -内酰胺酶的来源、流行病学特点、分类及基因表达调控等方面进行综述。
In recent years, studies have shown that plasmid-mediated AmpCβ-lactamase is mainly produced by Enterobacteriaceae bacteria and has a broader spectrum of hydrolyzed substrates than ESBLs and can effectively hydrolyze the third generation cephalosporins, Class antibiotics, and not inhibited by enzyme inhibitors. Carrying the gene encoding ampC gene plasmid rapid replication and transferability, leading to the spread of drug resistance, to clinical treatment brought great difficulties. This review summarizes the origin, epidemiological characteristics, classification and regulation of gene expression of AmpC beta - lactamase.