论文部分内容阅读
目的 探讨肿瘤相关抗原表达对胆囊癌早期诊断及其预后判断的价值。方法 采用免疫组化染色对 10例慢性胆囊炎、10例胆囊腺瘤及 5 0例胆囊癌组织的癌胚抗原 (CEA)、癌相关粘液抗原 (CA5 0 )、钙粘附蛋白E(E CD)及增殖细胞核抗原 (PCNA )的表达进行检测。结果 胆囊癌组织中CEA及CA5 0表达阳性率显著高于腺瘤组和胆囊炎组(P<0 .0 5 ) ,而E CD表达阳性率明显降低 ,且伴有转移的胆囊癌E CD表达更低。胆囊癌的PCNA标记指数显著高于胆囊炎组和腺瘤组 (P<0 .0 1)。CEA及PCNA过度表达者 3年生存率显著降低 (P<0 .0 1) ,E CD过度表达者 3年生存率较阴性者明显增高 (P<0 .0 5 )。结论 CEA、CA5 0以及PCNA检测可能有助于胆囊腺瘤恶变和胆囊癌的早期诊断 ,且CEA、PCNA和E CD检测可作为胆囊癌预后判断的参考指标
Objective To investigate the value of tumor associated antigen expression in the early diagnosis and prognosis of gallbladder cancer. Methods Immunohistochemical staining was used to detect CEA, CA5 0, E CD in 10 cases of chronic cholecystitis, 10 cases of gallbladder adenoma and 50 cases of gallbladder carcinoma. ) And proliferating cell nuclear antigen (PCNA) expression were detected. Results The positive rates of CEA and CA5 0 in gallbladder carcinomas were significantly higher than those in adenomas and cholecystitis groups (P <0.05), while the positive rate of E CD was significantly lower Lower. The PCNA labeling index of gallbladder carcinoma was significantly higher than that of cholecystitis and adenoma (P <0.01). The 3-year survival rates of patients with overexpression of CEA and PCNA were significantly lower than those of patients with overexpression of E CD (P <0.01). Conclusions The detection of CEA, CA5 0 and PCNA may contribute to the malignant transformation of gallbladder adenoma and the early diagnosis of gallbladder carcinoma. CEA, PCNA and E CD may be used as reference indicators for the prognosis of gallbladder carcinoma