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目的 探讨高原失血性休克兔,用不同浓度的氧合兼输液对其血气和血管紧张素Ⅱ的影响。方法 4 2只家兔分6组,在模拟35 0 0m高原低压舱内,放血,并维持血压在4 0mmHg 1h ,后用不同浓度氧合并输2倍于失血量的平衡液治疗,另设对照组。在休克前、后不同时相点分别采集血样,测动脉氧分压,HCO-3 、血管紧张素Ⅱ含量,并观察动物急性死亡情况。结果 用80 %氧合并输液的一组动物存活时间最长、4h存活率最高。血管紧张素Ⅱ在休克后明显升高,但氧疗后无明显变化。结论 对高原失血性休克兔需用较高浓度氧疗合并输液复苏。氧疗对血管紧张素Ⅱ并没有明显影响。
Objective To investigate the effects of different concentrations of oxygenated infusion solution on blood gas and angiotensin Ⅱ in high altitude hemorrhagic shock rabbits. Method 4: The 2 rabbits were divided into 6 groups. Blood was exsanguinated in the hypobaric chamber at a height of 350 m. The blood pressure was maintained at 40 mmHg for 1 h. The rabbits were treated with different concentrations of oxygen and 2 times of blood loss. group. Blood samples were taken at different time points before and after shock, and the arterial partial pressure of oxygen, HCO-3 and angiotensin Ⅱ were measured and the acute death of animals was observed. Results A group of animals with 80% oxygen infusion had the longest survival time and the highest survival rate at 4 hours. Angiotensin Ⅱ was significantly increased after shock, but no significant changes after oxygen therapy. Conclusions Altitude hemorrhagic shock rabbits need higher concentration oxygen therapy and infusion resuscitation. Oxygen therapy has no significant effect on angiotensin II.