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目的探讨急性冠脉综合征(ACS)患者,入院即刻床旁检测(POCT)N末端B型钠尿肽原(NT-proBNP)的临床应用价值。方法应用加拿大Response Biomedical公司RAMP(r)(锐普)荧光干式定量分析仪,检测63例ACS患者血中NT-proBNP的水平,分析其与年龄、临床心功能分级、B超左室射血分数(LVEF)以及住CCU时间、住院时间之间的关系。结果血液NT-proBNP测值<125ng/L与≥125ng/L组比较,前者平均年龄较小(55±10.4岁VS69.7±10.5岁,P<0.05),LVEF值较高(63.1%±8.0%VS56.8%±13.5%,P<0.05),平均住CCU时间较短(3.3±1.1天VS4.7±3.8天,P<0.05),平均住院时间也较短(9.8±3.0天VS14.6±10.1天,P<0.05)。结论入院即刻以POCT法测定血中NT-proBNP水平,有助于ACS患者疾病严重程度的判断,为临床诊疗提供依据。
Objective To investigate the clinical value of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute coronary syndrome (ACS) admitted to hospital immediately after bedside test (POCT). Methods The levels of NT-proBNP in 63 patients with ACS were measured by RAMP (r) (RAP) quantitative dry-type quantitative analyzer from Response Biomedical Inc. in Canada. The correlation between age, clinical function, Score (LVEF) and the relationship between CCU time and hospital stay. Results The mean age of the former was lower (55 ± 10.4 vs 69.9 ± 10.5 years, P <0.05), and the LVEF was higher (63.1% ± 8.0 % VS56.8% ± 13.5%, P <0.05). The mean duration of CCU stay was shorter (3.3 ± 1.1 days VS4.7 ± 3.8 days, P <0.05) and the average hospital stay was shorter (9.8 ± 3.0 days VS14). 6 ± 10.1 days, P <0.05). Conclusion The determination of NT-proBNP levels in blood by POCT immediately after admission is helpful to judge the severity of disease in ACS patients and provide the basis for clinical diagnosis and treatment.