内质网是真核细胞中最重要的膜性细胞器之一,其功能主要有蛋白质合成、折叠与修饰及将蛋白质运送到细胞中合适的位置。内质网分子伴侣如GRP78、GRP94、钙联蛋白和钙网蛋白等组成疏水性结构域,促进未折叠蛋白正确折叠和蛋白质之间的集聚。内质网通过对蛋白质折叠水平细微变化的检测,并将这些信息传递给细胞的其他部分,通过系统调节产生应答。由于各种应激如心肌梗死、缺血再灌注损伤等伤害性刺激导致细胞内质网内蛋白质折 Endoplasmic reticulum (ER) is one of the most important membrane organelles in eukaryotic cells. Its functions mainly include protein synthesis, folding and modification, and transport of proteins to appropriate locations in cells. Endoplasmic reticulum chaperones, such as GRP78, GRP94, calreticulin and calreticulin, form a hydrophobic domain that promotes the proper folding of unfolded proteins and the aggregation of proteins. Endoplasmic reticulum through the detection of subtle changes in the level of protein folding, and the information is passed to other parts of the cell, the system regulates the response. Due to various stress such as myocardial infarction, ischemia-reperfusion injury and other noxious stimuli lead to endoplasmic reticulum protein fold