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目的研究老年痴呆伴有高血压患者常用的降压药的临床使用疗效及安全性。方法共收集老年科2011~2014年住院老年人痴呆伴有高血压患者共64例(其中老年性痴呆39例,血管性痴呆15例,混合性痴呆10例),统计入组患者使用的降压药和抗痴呆用药,服药剂量,合并用药、临床疗效及不良反应。结果老年痴呆伴有高血压患者最主要服用的降压药是钙通道阻滞剂,其中使用氨氯地平(包括左旋氨氯地平)患者占总人数的65.6%。患者服药前后血压明显的降低(P<0.05)且患者血压得到有效控制,不良反应发生率低。结论钙通道阻滞剂在老年痴呆伴有高血压患者人群使用较为广泛,且具有疗效显著,安全性高的特点。
Objective To study the clinical efficacy and safety of commonly used antihypertensive drugs in patients with senile dementia complicated with hypertension. Methods Totally 64 senile dementia patients with hypertension were enrolled in the geriatric department from 2011 to 2014 (including 39 senile dementia, 15 vascular dementia and 10 mixed dementia) Medicine and anti-dementia medication, medication dose, combination therapy, clinical efficacy and adverse reactions. Results The most commonly used antihypertensive drugs for patients with Alzheimer’s disease and hypertension were calcium channel blockers, of which 65.6% of the patients were taking amlodipine (including levamlodipine). Before and after taking the drug significantly lower blood pressure (P <0.05) and blood pressure was effectively controlled, the incidence of adverse reactions is low. Conclusion Calcium channel blockers are widely used in people with Alzheimer’s disease accompanied with hypertension, and have the characteristics of significant curative effect and high safety.