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胃癌是全世界最常见的恶性肿瘤之一,发病率位居恶性肿瘤的第四位,死亡率位居癌症中的第二位[1]。胃癌的发生是一个多因素、多步骤的过程,包括癌基因、抑癌基因改变。临床上,胃癌因缺少特异性症状而早期诊断十分困难,手术切除是治疗胃癌的主要手段,但在晚期胃癌预后仍然很差。微小RNA(microRNA,miRNA)是真核生物中一类长度约22 nt的单链非编码小分子RNA,其编码基因存在于基因组的基因间隔区或内含子
Gastric cancer is one of the most common malignancies in the world. Its incidence is the fourth highest in malignant tumors and its mortality rate ranks the second among cancers [1]. The occurrence of gastric cancer is a multi-factor, multi-step process, including oncogenes and tumor suppressor genes. Clinically, the early diagnosis of gastric cancer due to lack of specific symptoms is very difficult, surgical resection is the main means of treatment of gastric cancer, but the prognosis of advanced gastric cancer is still poor. MicroRNAs (miRNAs) are a class of single-stranded, non-coding small RNAs of about 22 nt in eukaryotes whose coding genes are found in the genome’s intergenic regions or introns