目的了解沙门菌鞭毛抗原的变异及解决办法。方法从我们1988-2006年共收集的35株沙门菌中选出发生H-O变异的菌株4株进行试验。结果4株菌株用常规方法无法将沙门菌分到型,而用改进的试验方法可以鉴定到型,35株沙门菌检出4株H-O变异株,本次H-O变异率为11.4%。结论研究检测沙门菌H-O抗原的变异对追踪传染源、分析流行趋势有帮助。 Objective To understand the variation of Salmonella flagellar antigen and its solution. Methods Four strains of H-O isolates were selected from 35 Salmonella collected from 1988 to 2006 in our laboratory. Results Four strains could not be divided into two types by conventional methods. However, four strains of H-O were detected by 35 Salmonella strains with the improved method. The H-O mutation rate was 11.4%. Conclusion The study of detection of the variation of Salmonella H-O antigen is helpful for tracking the source of infection and analyzing the epidemic trend.