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目的:探讨多层螺旋CT冠状动脉成像(MSCT冠状动脉成像)、超敏C反应蛋白(sCRP)和心肌肌钙蛋白I(cTnI)在急性冠脉综合征的联合应用价值及相互关系。方法:稳定型心绞痛(SA)组为对照组,急性冠脉综合征(ACS)组分为不稳定型心绞痛(UA)组及急性心肌梗死(AM I)组,3组受试患者进行sCRP、cTnI和MSCT冠状动脉成像检查,比较2组sCRP、cTnI水平和MSCT冠状动脉成像结果,并对狭窄程度以及不同性质斑块间sCRP和cTnI水平进行比较。结果:ACS组sCRP、cTnI均显著高于SA组,2组间sCRP、cTnI水平差异有显著性(P<0.01)。两组冠脉狭窄程度比较差异有显著性,即ACS组以轻、中度狭窄为主,SA组以重度狭窄为主。结论:多层螺旋CT冠状动脉成像联合sCRP和cTnI检查,对判断冠脉病变程度及稳定性具有较高的敏感性和准确度,有利于ACS的诊断、治疗及预后评价。
Objective: To investigate the value and correlation of multislice spiral CT coronary angiography (MSCT coronary angiography), sCRP and cTnI in acute coronary syndrome. Methods: The group of stable angina pectoris (SA) was the control group, the group of acute coronary syndrome (ACS) was unstable angina pectoris (UA) and the group of acute myocardial infarction (AMI) cTnI and MSCT coronary angiography were performed. The sCRP, cTnI levels and MSCT coronary angiography were compared between the two groups. The sCRP and cTnI levels were compared between the stenosis and the different plaques. Results: The levels of sCRP and cTnI in ACS group were significantly higher than those in SA group. The levels of sCRP and cTnI in two groups were significantly different (P <0.01). There was significant difference between the two groups in the degree of coronary stenosis, that is, ACS group with mild to moderate stenosis, SA group with severe stenosis. Conclusions: MSCT combined with sCRP and cTnI examination is of high sensitivity and accuracy in judging the severity and stability of coronary artery disease. It is helpful for the diagnosis, treatment and prognosis of ACS.