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目的:评价拉莫三嗪与丙戊酸钠联用对儿童难治性癫痫的临床疗效。方法:选取医院2014年12月—2015年12月收治的难治性癫痫患儿50例,给予拉莫三嗪与丙戌酸钠联用治疗,以随访方式观察患者治疗8月后的临床疗效,评价患者癫痫发作率。结果:治疗8月后患者的病情控制的总有效率为96.00%;不良反应的发生率为12.00%。结论:拉莫三嗪与丙戌酸钠联用于治疗难治性癫痫患儿,能控制患儿的临床症状和缓解其肌肉痉挛,针对性地改善患者的癫痫发作症状,其临床疗效显著。
Objective: To evaluate the clinical efficacy of lamotrigine combined with valproate in refractory epilepsy in children. Methods: Fifty patients with refractory epilepsy admitted from December 2014 to December 2015 in our hospital were enrolled. Combined with lamotrigine and sodium valproate, the clinical efficacy was observed after 8 months of follow-up. Evaluation of patients with seizure rate. Results: After 8 months of treatment, the total effective rate of patients’ condition control was 96.00%. The incidence of adverse reactions was 12.00%. Conclusion: Lamotrigine combined with sodium valproate in the treatment of children with refractory epilepsy can control the clinical symptoms and relieve muscle spasms in children, and improve the symptoms of seizures in patients. The clinical efficacy is significant.