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已知光-暗周期和短暂的光暴露可影响动物体内生物钟的运行和位相变化,从而对昼夜节律产生规化作用.在哺乳动物中,光照的这种作用是通过起始于视网膜、终止于下丘脑视交叉上核(SCN)的视丘下管而实现的.药理学研究表明,光-暗信息的传递过程需要有乙酰胆碱(ACh)的参与.据此可以设想,胆碱能神经递质的阻断应能影响光的位移效应.为了证实这种可能性,对金黄色仓鼠进行实验.在持续黑暗、自行节律的条件下,给仓鼠腹腔注射抗胆碱药美加明450μg,10min后,光照暴露5min,然后观察24h内仓鼠昼夜活动节律的位相变化.
It is known that light-dark cycles and brief light exposure can affect circadian clock movement and phase changes in animals, thereby normalizing circadian rhythms.In mammals, this effect of light is initiated by the retina terminating in Hypothalamic suprachiasmatic nucleus (SCN) of the hypothalamus and pharmacological studies have shown that the light - dark information transmission process requires the involvement of acetylcholine (ACh) It can be assumed that the cholinergic neurotransmitter To confirm this possibility, experiments were performed on golden hamsters.Under dark, self-paced conditions, hamsters were injected intraperitoneally with 450 μg of anticholinergic mecamylamine 10 min after exposure to light for 5 min , And then observe the circadian rhythms of hamsters in 24 hours.