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目的探讨血、尿ＩＬ－６检测在肾移植急性排斥（ＡＲ）诊断及鉴别诊断中的作用。方法应用ＥＬＩＳＡ技术，分别对肾移植术后不同状态下患者血、尿ＩＬ－６水平进行检测。结果急性排斥及感染患者血ＩＬ－６水平较环孢素（ＣｓＡ）中毒、急性肾小管坏死（ＡＴＮ）、移植肾功能正常及正常对照组高。尿ＩＬ－６在急性排斥及感染组也较ＣｓＡ中毒、ＡＴＮ、移植肾功能正常组有明显升高，而急性排斥组较感染组升高更明显。结论血、尿ＩＬ－６水平的升高可作为判断肾移植急性排斥的指标之一；也可作为鉴别急性排斥反应与ＣｓＡ中毒、ＡＴＮ的重要参考指标；对鉴别急性排斥反应和感染具一定的参考价值
Objective To investigate the role of blood and urine IL-6 in the diagnosis and differential diagnosis of acute rejection (AR) in renal transplantation. Methods The levels of IL-6 in blood and urine of patients undergoing renal transplantation were detected by ELISA. Results The levels of blood IL-6 in patients with acute rejection and infection were significantly higher than those in CsA, ATN, and normal renal transplant recipients. Urinary IL-6 in acute rejection and infection group than CsA poisoning, ATN, renal transplant function in normal group was significantly increased, while the acute rejection group than in infected group increased more significantly. Conclusion The elevated blood levels of IL-6 in urine and urine can be used as an index to judge the acute rejection of renal allografts. It can also be used as an important reference index to differentiate acute rejection from CsA poisoning and ATN, and to identify acute rejection and infection Reference value