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目的探讨分析成人心肺复苏后缺氧缺血性脑病(AIE)的临床特征及脑电图特点。方法回顾性分析54例心肺复苏后AIE患者的临床资料。结果 15例继发癫痫,其中4例急性肌阵挛发作,6例迟发性肌阵挛发作,1例部分性发作,3例强直-阵挛发作,1例短暂的四肢抽搐、双眼上翻。10例患者接受脑电图检查,Ⅰ级1例,Ⅲ级5例,Ⅳ级4例。有14例患者行抗癫痫药物治疗,共使用6种抗癫痫药物,1例患者使用奥卡西平联合拉莫三嗪,余13例患者均有使用丙戊酸钠,其中7例患者有联合用药;14例患者用药后住院期间未再发作。结论肌阵挛是AIE中最常见的发作类型,脑电图改变与其病情较为一致,常需要多种药物的联合使用。
Objective To investigate the clinical characteristics and electroencephalogram characteristics of hypoxic-ischemic encephalopathy (AIE) after adult cardiopulmonary resuscitation (CPR). Methods The clinical data of 54 patients with AIE after cardiopulmonary resuscitation were retrospectively analyzed. Results 15 cases of secondary epilepsy, including 4 cases of acute myoclonic seizures, 6 cases of delayed myogenic seizures, 1 case of partial seizures, 3 cases of tonic-clonic seizures, 1 case of short limbs convulsions, double-ended . Ten patients underwent electroencephalography, one in grade I, five in grade III and four in grade IV. 14 patients were treated with anti-epileptic drugs, a total of 6 kinds of antiepileptic drugs were used, 1 patient used oxcarbazepine combined with lamotrigine, more than 13 patients were used sodium valproate, of which 7 patients were combined ; 14 patients did not attack during hospitalization after treatment. Conclusion Myoclonus is the most common type of seizure in AIE. Changes of EEG are more consistent with those of AIE and often require the combination of multiple drugs.