应用间接酶标法对人体不同组织类型的61例肺癌进行了CEA单克隆抗体的免疫组化研究,鳞癌阳性率为92％,腺癌86.7％。CEA在鳞癌呈明显的细胞异质性分布,在同一癌巢中,仅位于癌巢中心、分化较好的细胞CEA阳性。CEA在鳞癌呈膜性分布;腺癌为胞浆分布。尽管鳞癌和腺癌CEA阳性率较高,但对其应用于示踪导向疗法的价值尚有待探讨。 Immunohistochemical study of CEA monoclonal antibody in 61 cases of human lung cancer with different tissue types was performed by indirect enzyme labeling method. The positive rate of squamous cell carcinoma was 92%, and adenocarcinoma was 86.7%. CEA showed a significant heterogeneity in squamous cell carcinoma. In the same cancer nest, CEA was positive only at the center of the cancer nest and well-differentiated cells. CEA is membraney in squamous cell carcinoma; adenocarcinoma is cytoplasmic. Although the positive rate of CEA in squamous cell carcinoma and adenocarcinoma is high, the value of its application to tracer-guided therapy remains to be explored.