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目的探讨克罗米芬结合人绒毛膜促性腺激素治疗多囊卵巢综合征的临床效果。方法选取2012年1月至2013年4月郑州大学第三附属医院收治的多卵巢综合征患者68例,按数字法随机分为观察组与对照组,每组34例,对照组给予克罗米芬治疗,观察组给予克罗米芬结合人绒毛膜促性腺激素治疗,比较两组患者的临床治疗效果、各项临床指标及不良反应。结果经联合治疗后,观察组总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组正常月经、无卵巢发育、黄素化囊肿、卵泡闭锁等与对照组比较差异无统计学意义(P>0.05);观察组妊娠及妊娠率明显优于对照组,差异有统计学意义(P<0.05);观察组不良反应总发生率与对照组比较差异无统计学意义(P>0.05)。结论克罗米芬结合人绒毛膜促性腺激素治疗多囊卵巢综合征临床效果显著,能明显改善患者的妊娠情况,值得在临床上推广与应用。
Objective To investigate the clinical efficacy of clomiphene in combination with human chorionic gonadotropin in the treatment of polycystic ovary syndrome. Methods Sixty-eight patients with polycystic ovary syndrome admitted from the Third Affiliated Hospital of Zhengzhou University from January 2012 to April 2013 were randomly divided into observation group and control group according to the digital method, with 34 cases in each group. The control group was given clomiphene citrate treatment , The observation group was given clomiphene citrate combined with human chorionic gonadotropin treatment, the clinical efficacy of the two groups were compared, the clinical indicators and adverse reactions. Results After combined treatment, the total effective rate in the observation group was significantly higher than that in the control group (P <0.05). There was no statistical difference in the observation group between normal menstruation, ovarian development, luteinizing cyst and follicular atresia (P> 0.05). Pregnancy and pregnancy rates in the observation group were significantly better than those in the control group (P <0.05). There was no significant difference in the total incidence of adverse reactions between the observation group and the control group (P> 0.05). Conclusion Clomiphene combined with human chorionic gonadotropin treatment of polycystic ovary syndrome significant clinical effect, can significantly improve the pregnancy of patients, it is worth in the clinical promotion and application.