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目的探讨持续血液透析滤过对尿毒症患者血清炎症指标与心脏结构的影响。方法随机选取我院59例尿毒症患者,观察组30例给予持续血液透析滤过治疗,对照组29例给予常规血液透析治疗。比较治疗前后的血清炎症指标与心脏结构之间的差异。结果经治疗,患者的血压降低明显、睡眠与食欲好转,观察组症状缓解情况优于对照组,但差异无统计学意义(P>0.05);治疗后CRP、IL-6、IL-8、TNF-α、Ab与Hb显著优于治疗前(P<0.05);观察组治疗后左房内径(LAD)、左心室舒张期内径(LVDd)、左心室收缩期内径(LVDs)、后室间隔舒张末期厚度(IVSTd)、左室收缩末期内径(LVPWTd)与左心射血分数(LVEF)显著优于治疗前,且均显著优于对照组,差异有统计学意义(P<0.05)。结论持续血液透析滤过治疗尿毒症的疗效佳,可显著改善患者的炎症状态与延缓心脏结构的改变。
Objective To investigate the effect of continuous hemodiafiltration on serum inflammation and cardiac structure in uremic patients. Methods A total of 59 patients with uremia in our hospital were randomly selected. Thirty patients in the observation group were given continuous hemodiafiltration and 29 in the control group were given routine hemodialysis. The difference between serum inflammation index and cardiac structure before and after treatment was compared. Results After treatment, the blood pressure of the patients decreased significantly, and the sleep and appetite improved. The symptom relief in the observation group was better than that in the control group, but the difference was not statistically significant (P> 0.05). The levels of CRP, IL-6, IL- (P <0.05). The left atrium diameter (LAD), left ventricular diastolic diameter (LVDd), left ventricular systolic diameter (LVDs), and ventricular septal diastole in the observation group after treatment were significantly higher than those before treatment IVSTd, LVPWTd and LVEF were significantly better than those before treatment, and were significantly better than the control group (P <0.05). Conclusion Continuous hemodiafiltration treatment of uremia with good effect, can significantly improve the patient’s inflammatory state and delay the changes in cardiac structure.