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目的探讨妊娠晚期脐动脉血流S/D比值、妊娠特异性β1糖蛋白(pregnancy-specificβ1 glycoprotein,SP1)水平与妊娠期并发症及不良妊娠结局的关系。方法选取100例正常妊娠妇女为正常组,247例妊娠合并症患者作为妊娠并发症组,妊娠并发症组包括109例妊高症妇女(其中重度妊高症47例、轻度妊高症62例)、妊娠期糖尿病妇女73例、妊娠期羊水过少妇女65例分别与妊娠晚期进行脐动脉血流S/D比值、血清SP1水平测定。结果妊娠合并症组、重度妊高症组、GDM组、羊水过少组妊娠妇女的脐动脉血流S/D值显著的高于正常组妊娠妇女且差异均有统计学意义(均P<0.05),妊娠合并症组、重度妊高症组的血清SP1水平显著的低于正常组妊娠妇女且差异有统计学意义(P<0.05),妊娠合并症组妇女的早产率、胎膜早破率、产后出血率均高于正常组妊娠妇女且差异均有统计学意义(均P<0.05),妊娠合并症组胎儿窘迫率、新生儿窒息率均高于正常组且差异有统计学意义(均P<0.05)。结论妊娠晚期脐动脉血流S/D比值升高、血清SP1降低水平提示母婴不良结局发生率增加。
Objective To investigate the relationship between S-D ratio and pregnancy-specific β1 glycoprotein (SP1) levels in umbilical artery during late pregnancy and pregnancy complications and adverse pregnancy outcomes. Methods 100 normal pregnant women were selected as the normal group, 247 pregnant women with complications of pregnancy as a group of pregnancy complications, pregnancy complications group including 109 cases of pregnancy-induced hypertension (including 47 cases of severe pregnancy-induced hypertension, 62 cases of mild pregnancy-induced hypertension ), 73 cases of gestational diabetes mellitus, 65 cases of oligohydramnios in gestational age, respectively, and umbilical artery blood flow in late pregnancy S / D ratio, serum SP1 levels were determined. Results The S / D values of umbilical arterial blood flow in pregnant women with gestational complications, severe PIH, GDM group and oligohydramnios group were significantly higher than those in normal pregnant women (all P <0.05 ), Gestational complications group, severe pregnancy-induced hypertension group serum SP1 levels were significantly lower than the normal pregnant women and the difference was statistically significant (P <0.05), pregnancy complications in women preterm birth rate, premature rupture of membranes rate , The rate of postpartum hemorrhage was higher than that of the normal pregnant women (all P <0.05). The rate of fetal distress and neonatal asphyxia in pregnancy complicating group were higher than those in normal group (all P <0.05), both of which were statistically significant P <0.05). Conclusion The S / D ratio of umbilical artery blood flow in the third trimester of pregnancy increased, and the serum level of SP1 decreased, which suggested that the incidence of maternal and fetal adverse outcomes increased.