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目的：了解亚热带地区糖尿病（ＤＭ）流行状况，探讨非超重的Ⅱ型糖尿病中胰岛素依赖者（ＩＴＤＭ）的诊断分型。方法：①按照１９８５年ＷＨＯ诊断标准及全国统一的流行调查方法进行，患病率用１９９０年全国人口结构及世界人口结构进行标化；②利用ＰＣＲ／ＳＳＤ方法在ＩＤＤＭ，ＩＴＤＭ及健康对照组作ＨＬＡＤＱＢ１的基因分型；③用酶联免疫法Ｅｌｉｓａ测ＩＣＡ及ＧＡＤ－Ａｂ；④用放免法测血清Ｃ肽，胰高糖素及胰岛素专一受体的浓度及亲合力；⑤胰腺Ｂ超或ＣＴ检查。结果：①１９９４年我区ＤＭ患病率为２．４３％，世界标化率为３．００％，非超重ＤＭ占总体５６．１％；②ＩＤＤＭ组ＤＱＢ１各等位基因频率，＊０２０１，＊０３０２比健康对照组明显增高（Ｐ＜０．０１），ＩＴＤＭ组中＊０２０１有６／２２高于ＩＤＤＭ组，＊０５０２明显高于ＩＤＤＭ组及健康对照组；③ＩＤＤＭ组ＩＣＡ（＋）为３６．４％，ＧＡＤ－Ａｂ（＋）为６６．６％，ＩＴＤＭ组ＧＡＤ－Ａｂ（＋）为５４％；④４例胰腺ＣＴ有萎缩及钙化。结论：①亚热带地区１９９４年ＤＭ患病率为２．４３％，比１９８０年患病率高２．２５倍。按ＨＫｉｎｇ划分此地ＤＭ流行已达到世界中等水平；②ＤＱＢ１基因分型及ＩＣＡ，Ｇ?
Objective: To understand the prevalence of diabetes mellitus (DM) in subtropical regions and to explore the diagnostic typing of insulin dependent patients (ITDM) in non-overweight type 2 diabetes mellitus. Methods: ①According to the WHO diagnostic criteria of 1985 and the national uniform epidemiological survey method, the prevalence was standardized by the population structure of the whole country in 1990 and the world population structure; ② Using PCR / SSD method in IDDM, ITDM and healthy control group HLADQB1 genotyping; ③ ELISA Elisa ICA and GAD-Ab; ④ radioimmunoassay serum C-peptide, glucagon and insulin-specific receptor concentration and affinity; ⑤ pancreatic ultrasound B or CT examination. Results: ① In 1994, the prevalence of DM in our district was 2.43%, the standardization rate in the world was 3.00% and the non-overweight DM accounted for 56.1% of the total. ② The frequencies of DQB1 alleles, * 0201, * 0302 The level of * 0201 in ITDM group was significantly higher than that in IDDM group (* 0201), * 0502 was significantly higher than IDDM group and healthy control group; (3) ICA (+) in IDDM group was 36.4 %, GAD-Ab (+) was 66.6%, and GAD-Ab (+) was 54% in ITDM group. Conclusion: (1) The prevalence of DM in subtropical region in 1994 was 2.43%, 2.25 times higher than that in 1980. According to HKing, the epidemic of DM here has reached the middle level of the world; ②DQB1 genotyping and ICA, G?