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目的 本研究观察大剂量胸腺肽对恶性血液病化疗病人T细胞亚群的影响。方法 分化疗加胸腺肽组(实验组)和单纯化疗组(对照组),实验组于化疗同时每日静点胸腺肽100mg,连续10～14天后检测T淋巴细胞亚群的变化。结果 实验组化疗后CD3、CD4和CD56(NK)阳性百分率及CD4/CD8比值均明显高于本组化疗前和对照组化疗后水平。结论 大剂量胸腺肽可在短时间内提高恶性血液病化疗病人机体的免疫功能。
Objective To observe the effects of high dose thymosin on T lymphocyte subsets in patients with hematologic malignancies. Methods Thymosin (experimental group) and chemotherapy alone group (experimental group) were divided into two groups. The experimental group was treated with 100 mg of thymosin daily, and the changes of T lymphocyte subsets were detected after 10 to 14 days. Results The positive percentage of CD3, CD4 and CD56 (NK) and the ratio of CD4 / CD8 in the experimental group after chemotherapy were significantly higher than those before chemotherapy and in the control group after chemotherapy. Conclusion High-dose thymosin can improve the immune function of patients with chemotherapy of hematologic malignancies in a short time.