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目的探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者呼吸困难及运动耐力与生活质量的相关性。方法随机选择2009年5月—2011年4月在日照市结核病防治所门诊就诊的COPD稳定期患者108例,计算BMI、测试肺功能、评估呼吸困难程度、评定运动耐力、评估生活质量,计量资料用±s表示,相关性采用直线相关分析,除呼吸困难评级数据不服从正态分布,其他各参数均服从正态分布,因此呼吸困难与生活质量的相关性采用Spearman秩和相关检验,其他均采用Pearson积矩相关检验。P<0.05为差异有统计学意义。结果呼吸困难及运动耐力与生活质量的相关性显著(r=0.749、0.676,P<0.05);肺功能1 s用力呼气容积(forced expiratory volume in one second,FEV1)、用力肺活量(force vital capacity,FVC)与生活质量虽有相关性,但是相关性较弱(r=0.355、0.341,P<0.05);BMI与生活质量的相关性无统计学意义(P>0.05)。将BMI、FEV1%、FVC%、呼吸困难评估及运动耐力等作为自变量,生活质量总分作为应变量进行多元逐步回归分析,发现呼吸困难和运动耐力与生活质量独立相关,是影响生活质量的主要因素。结论呼吸困难程度和运动耐力可用于评估COPD患者生活质量,与肺功能比较效果更佳。
Objective To investigate the relationship between dyspnea and exercise tolerance and quality of life in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 108 COPD stable patients were selected from outpatient clinics in Rizhao TB Hospital from May 2009 to April 2011. BMI was calculated, lung function was measured, degree of dyspnea was assessed, exercise tolerance was assessed, quality of life was measured, measurement data Using ± s, the correlation using linear correlation analysis, except for dyspnea rating data does not obey the normal distribution, the other parameters are subject to normal distribution, so the relationship between dyspnea and quality of life using Spearman rank correlation test, other Pearson product of moment correlation test. P <0.05 for the difference was statistically significant. Results The correlation between dyspnea and exercise tolerance and quality of life was significant (r = 0.749,0.676, P <0.05); forced expiratory volume in one second (FEV1), force vital capacity , FVC) correlated with quality of life, but the correlation was weak (r = 0.355, 0.341, P <0.05). There was no significant correlation between BMI and quality of life (P> 0.05). BMI, FEV1%, FVC%, assessment of dyspnea and exercise tolerance were taken as independent variables, and the total score of life quality was used as dependent variable to conduct multiple stepwise regression analysis. It was found that dyspnea and exercise endurance were independently related to quality of life, which were the factors influencing quality of life major factor. Conclusions The degree of dyspnea and exercise endurance can be used to assess the quality of life in patients with COPD, compared with pulmonary function better.