本文报告红细胞浓度、起始原虫感染率以及培养时间等因素,对体外测定恶性疟原虫氯喹敏感性的影响。结果表明,使原虫减少50％(或95％)所需氯喹的浓度(SC_(50)或SC_(95)),与所观察的红细胞浓度(1.25～10％)呈正相关(γ值分别为0.94和0.92),与起始原虫感染率(0.5～4％)也呈正相关(γ值分别为0.95和0.99)。培养时间以48小时较适宜。 This article reports the red blood cell concentration, the initial protozoa infection rate and culture time and other factors on the determination of chloroquine sensitivity of Plasmodium falciparum. The results showed that the concentrations of chloroquine needed to reduce protozoa by 50% (or 95%) (SC_ (50) or SC_ (95)) were positively correlated with observed erythrocyte concentrations (1.25-10%) And 0.92 respectively), which was also positively correlated with the initial protozoal infection rate (0.5-4%) (γ values ​​were 0.95 and 0.99, respectively). Training time to 48 hours more appropriate.