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作者在 BALB/c小鼠中比较了基因枪接种与肌肉注射编码单个细胞毒性 T淋巴细胞 ( CTL )表位或卵白蛋白 ( OVA)的质粒DNA诱导的免疫应答重复性的异同。 李斯特菌溶血素 O( L LO)的 91 - 99寡核苷酸残基是一个 H- 2 Kd 限制性显性 T细胞表位。含 LL O 91 - 99寡核苷酸的质粒p91
The authors compared the similarities and differences in the repetitiveness of the immune responses induced by plasmid DNA between a gene gun and an intramuscular injection of a single cytotoxic T lymphocyte (CTL) epitope or ovalbumin (OVA) in BALB / c mice. The 91-99 oligonucleotide residues of Listeria hemolysin O (LLO) is an H-2 Kd-restricted dominant T cell epitope. Plasmid p91 containing LL O 91-99 oligonucleotides