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采用内溶法制备了由聚叠氮缩水甘油醚(GAP)改性的单基球形药,用扫描电子显微镜(SEM)、假密度测定器、激光粒度仪和傅里叶变换红外(FT-IR)对GAP改性单基球形药进行表征。结果表明,所制得的GAP改性单基球形药圆球率较高,颗粒间无粘结,流散性好;在驱溶时采取缓慢升高真空度和温度的方法可制得较好的GAP改性单基球形药,驱溶时间从10min增长至60min时,假密度从0.5467g/cm3增大至0.8315g/cm3,适宜的驱溶时间为40～50min;搅拌速度从700r/min提高至1 500r/min时,GAP改性单基球形药的中位粒径d50从134.53μm减小至59.80μm,适宜的搅拌速度为1 000～1 500r/min。
The monodisperse spherical particles modified by poly azide glycidyl ether (GAP) were prepared by an internal dissolution method and characterized by scanning electron microscopy (SEM), density measurement, laser particle sizer and Fourier transform infrared (FT-IR) ) Characterization of GAP modified monomelic spherical drug. The results showed that the GAP-modified monodisperse spherical particles had higher ball rate, no particle-to-particle adhesion and good fluidity. When the solution was slowly purged, the degree of vacuum and the temperature were increased. GAP modified monobasic spherical drug, the flooding time increased from 10min to 60min, the bulk density increased from 0.5467g / cm3 to 0.8315g / cm3, the suitable flooding time was 40 ~ 50min; the stirring speed increased from 700r / min At 1 500 r / min, the median diameter d50 of GAP modified monobasic spherical drug decreased from 134.53μm to 59.80μm, and the suitable stirring speed was from 1000 to 1 500r / min.