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目的探讨疏血通在改善糖尿病并发脑梗死患者血液流变学中的作用。方法选择2012年3月—2014年9月收治的糖尿病并发脑梗死患者80例,随机分为观察组和对照组各40例。对照组患者在常规降糖治疗基础上给予口服肠溶阿司匹林片0.1 g,1次/d,0.4 g胞二磷胆碱加250 ml生理盐水注射液静脉滴注,1次/d。观察组在对照组基础上给予4 ml疏血通注射液加250 ml生理盐水注射液静脉滴注,1次/d。两组均治疗2周。比较两组总有效率及全血粘度、血细胞比容、血浆粘度、红细胞聚集指数等血液流变学相关指标。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果观察组总有效率为95.0%,对照组为70.0%,差异有统计学意义(P<0.05)。观察组低切全血粘度、血浆粘度、纤维蛋白原水平[(8.68±1.19)、(1.68±0.26)m Pa·s、(4.09±0.22)g/L]均低于对照组[(9.55±1.19)、(1.82±0.31)m Pa·s、(5.18±0.20)g/L],差异均有统计学意义(均P<0.05)。结论疏血通能够有效改善糖尿病并发脑梗死患者的血液流变学,提高临床疗效,值得推广。
Objective To investigate the role of Shuxuetong in improving hemorrheology in patients with diabetes and cerebral infarction. Methods Eighty patients with diabetes mellitus and cerebral infarction who were admitted from March 2012 to September 2014 were randomly divided into observation group (40 cases) and control group (40 cases). Patients in the control group were given oral enteric-coated aspirin 0.1 g, once daily, 0.4 g citicoline plus 250 ml normal saline intravenously once a day on the basis of routine hypoglycemic treatment. The observation group was given intravenous drip of 4 ml Shuoxuetong injection plus 250 ml normal saline injection once a day on the basis of the control group. Both groups were treated for 2 weeks. The total effective rate and whole blood viscosity, hematocrit, plasma viscosity and erythrocyte aggregation index were compared between the two groups. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate was 95.0% in observation group and 70.0% in control group, the difference was statistically significant (P <0.05). The low-cut whole blood viscosity, plasma viscosity and fibrinogen level in the observation group were significantly lower than those in the control group [(9.55 ± 1.66), (1.68 ± 0.26) m Pa · s, (4.09 ± 0.22) g / L] 1.19), (1.82 ± 0.31) m Pa · s, (5.18 ± 0.20) g / L, respectively, with significant difference (all P <0.05). Conclusion Shuxuetong can effectively improve the blood rheology of patients with cerebral infarction and improve clinical efficacy, it is worth promoting.