[目的]探讨老年人服用非甾体抗炎药致上消化道出血的风险。[方法]回顾性分析2003年8月至2009年8月收治的因服用非甾体抗炎药致上消化道出血老年患者60例的临床资料。[结果]经过4～8周治疗,60例患者呕血、黑便停止,大便隐血试验阴性。上腹胀痛、上腹隐痛、上腹不适、返酸、嗳气、恶心、呕吐较入院时明显缓解。2个月后复查胃镜,胃、十二指肠球部溃疡、糜烂均痊愈。[结论]老年人服用非甾体抗炎药存在一定的上消化道出血风险,使用时应严格适应证,定期复查,尽量选用高选择性的环氧化酶抑制剂。 [Objective] To investigate the risk of upper gastrointestinal bleeding caused by taking NSAIDs in the elderly. [Method] The clinical data of 60 elderly patients with upper gastrointestinal hemorrhage who were taking NSAIDs admitted from August 2003 to August 2009 were retrospectively analyzed. [Result] After 4 to 8 weeks of treatment, 60 patients vomit blood, black stool stopped, fecal occult blood test was negative. Abdominal pain, abdominal pain, abdominal discomfort, back to acid, belching, nausea, vomiting significantly reduced when admitted to hospital. 2 months after the review gastroscopy, stomach, duodenal ulcer, erosion are cured. [Conclusion] Elderly people taking NSAIDs have a certain risk of upper gastrointestinal bleeding. When used, they should be strictly indicted and regularly reviewed. Highly selective cyclooxygenase inhibitors should be used as far as possible.