论文部分内容阅读
目的 探讨咪唑斯汀抗炎活性的产生机制。方法 大鼠鼠爪皮下注射0.1 mL的花生四烯酸(体积分数为0.003)诱导鼠爪水肿炎性动物模型。注射前灌胃分别给予咪唑斯汀、氯雷他定、西替利嗪(0.3 mg/kg),用千分尺测量肿胀足爪厚度,比较不同抗组胺药对鼠爪肿胀抑制程度的高低。分别给予大鼠5-脂氧合酶的直接抑制剂齐留通(3 mg/kg)和咪唑斯汀(0.3 mg/kg),比较2种药物对鼠爪肿胀抑制程度的高低。结果 咪唑斯汀显著抑制花生四烯酸诱导的鼠爪水肿,氯雷他定、西替利嗪对鼠爪水肿无抑制作用(P<0.01);齐留通显著抑制鼠爪水肿(P<0.01),对鼠爪水肿的抑制率与咪唑斯汀比较差异无显著性(P>0.05)。结论 咪唑斯汀可能通过抑制5-脂氧合酶活性的途径发挥其抗炎活性。
Objective To investigate the mechanism of anti-inflammatory activity of mizolastine. Methods Rat paw subcutaneously injected with 0.1 mL of arachidonic acid (volume fraction of 0.003) to induce murine paw edema inflammatory animal model. Mizolastine, loratadine and cetirizine (0.3 mg / kg) were given intragastrically before intragastric administration. The thickness of swollen paws was measured by micrometer, and the inhibitory effect of different antihistamines on mouse paw swelling was compared. Zileuton (3 mg / kg) and mizolastine (0.3 mg / kg), the direct inhibitors of 5-lipoxygenase, were respectively administered to rats. The inhibitory effect of the two drugs on rat paw swelling was compared. Results Mizolastine significantly inhibited arachidonic acid induced rat paw edema, loratadine and cetirizine did not inhibit mouse paw edema (P <0.01), while Qi Liu Tong significantly inhibited mouse paw edema (P <0.01) ), The inhibitory rate of mouse paw edema was no significant difference compared with mizolastine (P> 0.05). Conclusion Mizolastine may exert its anti-inflammatory activity by inhibiting the activity of 5-lipoxygenase.