论文部分内容阅读
甲胎蛋白的生物学特性仍不清楚,导致甲胎蛋白合成的机理仍是猜测性的。部分肝切除的大鼠,其血清出现甲胎蛋白;急性病毒性肝炎的患者,用放射免疫试验可观察到血清甲胎蛋白的浓度增高。这些结果均表明甲胎蛋白的合成过程伴随有肝细胞的再生。因此,血清甲胎蛋白的浓度如果能反映出肝细胞的再生,则在严重肝坏死后的增生期可出现高水平的甲胎蛋白。为了检验这种可能性,作者对不同严重程度的急性病毒性肝炎患者,探查甲胎蛋白与肝炎的严重程度及其预后的关系。
The biological characteristics of alpha-fetoprotein are still not clear, leading to the mechanism of alpha-fetoprotein synthesis is still speculative. Partial hepatectomy rats, the serum appears alpha-fetoprotein; patients with acute viral hepatitis, radioimmunoassay can be observed serum alpha-fetoprotein concentration increased. These results indicate that the synthesis of alpha-fetoprotein is accompanied by the regeneration of hepatocytes. Thus, serum alpha-fetoprotein concentrations, if reflecting hepatocyte regeneration, present high levels of alpha-fetoprotein during hyperplasia following severe hepatic necrosis. To test this possibility, the authors explored the relationship between the severity of AFP and hepatitis and their prognosis in patients with acute viral hepatitis of varying severity.