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目的探讨双环醇片治疗抗精神病药物所致肝损伤患者的临床疗效及安全性。方法选取2013年1月至2016年1月期间医院收治的74例因使用抗精神病药物所致肝损伤患者作为研究对象,根据其用药方案的不同分为甘草酸二铵组(34例)与双环醇片组(40例),比较两组患者的临床疗效及安全性。结果用药4周后,双环醇片组患者的临床疗效总有效率明显高于甘草酸二铵组,差异有统计学意义(P<0.05);治疗后,两组患者的天冬氨酸转氨酶(AST)、谷氨酸转氨酶(ALT)、谷氨酰转肽酶(γ-GT)、总胆红素(TBIL)水平均明显低于治疗前,且双环醇片组患者的AST、ALT、γ-GT、TBIL水平明显低于甘草酸二铵组,差异均有统计学意义(均P<0.05)。结论对抗精神病药物所致的肝损伤患者,给予双环醇片治疗可减少肝损伤,临床疗效显著,且安全性较高。
Objective To investigate the clinical efficacy and safety of bicyclic alcohol tablets in the treatment of liver injury induced by antipsychotics. Methods From January 2013 to January 2016, 74 patients with liver injury caused by antipsychotics were selected as the study subjects. According to the different regimens, diammonium glycyrrhizinate (34 cases) and bicyclohepta Alcohol group (40 cases), the clinical efficacy and safety of two groups were compared. Results After 4 weeks of treatment, the total effective rate of the patients in the bicyclic alcohol tablets group was significantly higher than that of the ammonium diammonium glycyrrhizinate group (P <0.05). After treatment, the aspartate aminotransferase AST, ALT, γ-GT and TBIL were significantly lower than those before treatment, and AST, ALT, γ -GT, TBIL levels were significantly lower than the group of ammonium glycyrrhizinate, the difference was statistically significant (P <0.05). Conclusion In patients with liver injury caused by psychotropic drugs, the administration of bicycloalcohol tablets can reduce liver injury, with significant clinical effect and high safety.