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ＨＢｓＡｇｐｒｅＳ１（２１－４７）肽参与乙肝病毒与肝细胞受体的结合。我们用固相法合成了ＨＢｓＡｇｐｒｅＳ１（２０－４７）２８肽，并用此肽与ＢＳＡ的偶联物免疫家兔；抗血清经亲和层析纯化后，得到了高纯度、高活力及专一性的抗ＨＢｓＡｇｐｒｅＳ１（２０－４７）多抗，它能成功地用于基因工程表达产物及病人血清中的ＰｒｅＳ１抗原的检测。
The HBsAgpreS1 (21-47) peptide is involved in the binding of hepatitis B virus to hepatocyte receptors. We synthesized HBsAgpreS1 (20-47) 28 peptide by solid-phase method and immunized rabbits with conjugate of this peptide and BSA. The antiserum was purified by affinity chromatography to obtain high purity, high activity and specificity Anti-HBsAgpreS1 (20-47) polyclonal antibody, which can be successfully used for the detection of genetically engineered expression products and PreS1 antigen in the patient’s serum.