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研究碘化钾、碘酸钾对大鼠甲状腺形态学结构的影响。将Wistar大鼠随机分为低碘组（LI），正常组（NI），碘化钾治疗组（KI），碘酸钾治疗组（KIO_3）；治疗3个月后观察甲状腺重量和形态学的变化，并做体视学分析。结果发现，LI组甲状腺相对重量明显高于NI组；LI组甲状腺滤泡及滤泡腔的平均体积VQ、平均表面积SQ、体积密度VV、表面积密度Sv均明显小于NI组，而数密度NV及比表面积S/V均明显高于NI组；治疗3个月后，KI组和KIO_3组的上述指标均有明显恢复，但尚未完全恢复正常。KI组和KIO3组之间各项指标无显著性差异。上述结果表明，低碘可致大鼠甲状腺肿大，甲状腺组织表现出典型的小滤泡增生性改变；KI和KIO_3治疗缺碘性甲状腺肿均有很好的疗效，在本实验期间两者的疗效无显著性差异。
To study the effects of potassium iodide and potassium iodate on the thyroid morphological structure in rats. Wistar rats were randomly divided into low iodine group (LI), normal group (NI), potassium iodide treatment group (KI) and potassium iodate treatment group (KIO_3). The changes of thyroid weight and morphology were observed 3 months after treatment, And do stereological analysis. The results showed that the relative weight of thyroid in LI group was significantly higher than that in NI group. The mean volume VQ, mean surface area SQ, volume density VV and surface area density Sv of thyroid follicular and follicular cavity in LI group were significantly lower than those in NI group. The specific surface area S / V were significantly higher than the NI group; 3 months after treatment, KI group and KIO_3 group of these indicators were significantly recovered, but not fully returned to normal. KI group and KIO3 group between the indicators no significant difference. The above results show that low iodine can cause thyroid enlargement in rats, thyroid tissue showed a typical small follicular hyperplasia; KI and KIO_3 treatment of iodine deficiency goiter have a good effect, both during the experiment No significant difference in efficacy.