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为研究人类乳头状瘤病毒（HPV）与肺癌发生的病因关系，采用聚合酶链（PCR）技术对石蜡包埋肺鳞癌、肺腺癌、肺鳞癌组织旁鳞状化生上皮、正常支气管粘膜进行HPV6／11、8、16、18、31／33及35型检测。结果表明：4种组织中，HPVDNA的总检出率分别为58％、33％、80％和13％，其中以HPV16型及HPV18型所占比例最高，HPV感染与肺鳞癌和腺癌的发生有一定的联系，鳞状上皮化生似可视为癌前病变。
To investigate the etiology of human papillomavirus (HPV) and lung cancer, polymerase chain PCR was used to paraffin-embedded lung squamous cell carcinoma, lung adenocarcinoma, squamous metaplastic epithelium, and normal bronchi The mucosa was tested for HPV 6/11, 8, 16, 18, 31/33, and 35. The results showed that the total detection rate of HPV DNA was 48%, 33%, 80%, and 13% in the four tissues, of which HPV16 and HPV18 were the highest. HPV infection was associated with lung squamous cell carcinoma and adenocarcinoma. Occurrence of some contact, squamous metaplasia may be seen as precancerous lesions.