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目的探讨老年急性脑梗死患者入院时血镁水平与短期预后的关系。方法选择2012年6月~2013年6月连续入住本院的老年急性脑梗死患者(发病时间≤24 h)为研究对象。回顾性收集患者的一般资料、生活方式危险因素、既往相关病史、基线时临床及实验室检查、TOAST分型;以患者入院后12 h内首次静脉血镁值将患者分为低血镁组(血镁≤0.7 mmol/L或1.7 mg/dL)和正常血镁组(血镁>0.7 mmol/L或1.7 mg/dL);比较2组出院时美国国立卫生研究院脑卒中量表(NIHSS)评分、改良Ranking量表(mRS)评分及脑卒中进展发生率。结果符合入组条件的患者共252例,低血镁组109例(43.3%);与正常血镁组比较,低血镁组吸烟者少见(25.7%vs 39.2%,P=0.025);2组年龄、性别、既往史、TOAST分型、入院时血钙、血糖以及脑卒中严重性比较无显著性差异;出院时低血镁组NIHSS评分显著高于正常血镁组(6分vs 5分,P=0.032);低血镁组脑卒中进展更常见(33.9%vs 22.4%,P=0.041)。结论血镁水平低的老年急性脑梗死患者脑卒中进展风险较高,短期预后不佳。
Objective To investigate the relationship between serum magnesium level and short-term prognosis in elderly patients with acute cerebral infarction. Methods Aged patients with acute cerebral infarction (onset time ≤ 24 h) admitted to our hospital from June 2012 to June 2013 were selected as the study subjects. Patients were retrospectively collected for general information, lifestyle risk factors, previous medical history, clinical and laboratory tests at baseline, and TOAST typing. Patients were divided into hypomagnesemia group (≤ 0.7 mmol / L or 1.7 mg / dL) and normal magnesium group (> 0.7 mmol / L or 1.7 mg / dL). The National Institutes of Health Stroke Scale (NIHSS) Score, improved rating scale (mRS) score and incidence of stroke progression. Results A total of 252 patients met the inclusion criteria and 109 patients (43.3%) received hypomagnesemia. Compared with normal magnesium group, smokers with hypomagnesemia were less common (25.7% vs 39.2%, P = 0.025) There was no significant difference of serum calcium, blood glucose and the severity of stroke when they were admitted to hospital on the basis of age, sex, past history, TOAST classification, NIHSS score at discharge of low magnesium group and significantly higher than that of normal magnesium group (6 vs 5, P = 0.032). The progression of stroke in hypomagnesemia group was more common (33.9% vs 22.4%, P = 0.041). Conclusion Elderly patients with acute cerebral infarction who have low levels of magnesium have a higher risk of stroke and poor short-term prognosis.