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目的评价原发性醛固酮增多症(原醛症)患者中代谢综合征的患病率。方法检测180例原醛症(PA)及29例原发性高血压患者(EH)的腰围、血压、血脂、空腹血糖、血、尿醛固酮、血、尿电解质、基础及激发血浆肾素活性,这些指标的结果与58例在我院进行健康体检的人群(对照组,C)的结果进行比较。结果(1)对所有研究对象进行代谢综合征相关指标的筛查,PA、EH及C 3组代谢综合征的患病率分别为40.6%(73/180)、13.8%(4/29)及13.8%(8/58)。(2)原醛症组代谢综合征的各项指标,如收缩压及舒张压高于原发性高血压及对照组,而高密度脂蛋白胆固醇低于其余两组,腰围、甘油三酯及空腹血糖高于对照组。(3)PA、EH及C 3组代谢综合征相关症状患病率比较以高血压最常见(分别为99.4%、100.0%、48.3%),高甘油三酯血症(分别为37.2%、24.1%、22.4%)及低高密度脂蛋白胆固醇血症(分别为37.8%、20.7%、22.4%)次之,腹型肥胖(分别为26.7%、17.2%、15.5%)及高血糖(分别为25.6%、10.3%、12.1%)最低。(4)伴或不伴代谢综合征的原醛症患者的血、尿醛固酮,PRA基础、激发值及血钾比较均无统计学差异。结论原发性醛固酮增多症患者代谢综合征的患病率升高。
Objective To evaluate the prevalence of metabolic syndrome in patients with primary aldosteronism (primary aldosteronism). Methods 180 cases of primary aldosteronism (PA) and 29 cases of essential hypertension (EH) were measured for waist circumference, blood pressure, blood lipid, fasting blood glucose, blood aldosterone, blood and urine electrolytes, basal and stimulated plasma renin activity, The results of these indicators were compared with the results of 58 healthy people in our hospital (control group, C). Results (1) The prevalence rates of metabolic syndrome in PA, EH and C 3 groups were 40.6% (73/180), 13.8% (4/29) and 13.8% (8/58). (2) The indexes of metabolic syndrome such as systolic and diastolic blood pressure in primary aldehyde group were higher than those in primary hypertension group and control group, while those in high-density lipoprotein cholesterol group were lower than the other two groups, waist circumference, triglyceride and Fasting blood glucose was higher than the control group. (3) The prevalence rates of metabolic syndrome-related symptoms in PA, EH and C 3 groups were the most common among those with hypertension (99.4%, 100.0% and 48.3%, respectively), hypertriglyceridemia (37.2% and 24.1 (22.7%, 22.4%) and low-density lipoprotein cholesterol (37.8%, 20.7% and 22.4%, respectively) followed by abdominal obesity (26.7%, 17.2% and 15.5% 25.6%, 10.3%, 12.1%) lowest. (4) There was no significant difference in blood, urine aldosterone, PRA basal, excitation value and serum potassium in the patients with primary aldosteronism with or without metabolic syndrome. Conclusion The prevalence of metabolic syndrome is increased in patients with primary aldosteronism.