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用５３ｋＤａ抗原单独或加佐剂经不同途径、以不同剂量免疫ＢＡＬＢ／ｃ小鼠，再用约氏疟原虫非致死株１０５ＰＲＢｃ／只攻击，观察各组小鼠血原虫率变化，比较血清抗体水平。５３ｋＤａ抗原２０μｇ／只加福氏完全佐剂经腹腔注射免疫２次可使小鼠产生有效的免疫保护。以腹腔注射产生的保护作用最好。
BALB / c mice were immunized with different doses of 53kDa antigen alone or with adjuvant, and then challenged with 105PRBc / non-lethal strain of Plasmodium yoelii to observe the changes of blood protozoa in mice. Serum antibody levels were compared. The mice were immunized with 53kDa antigen 20μg / only Freund’s complete adjuvant by intraperitoneal injection twice. Intraperitoneal injection of the best protection.