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目的:探讨冰片的抗血栓作用。方法:用血栓形成实验、血小板聚集实验及血小板内钙离子浓度的测定,考察冰片对血栓形成、血小板5-羟色胺(5-HT)含量、血小板聚集率及血小板内游离钙离子浓度[Ca2+]i的影响。结果:ig冰片粟米油溶液140 mg.kg-1,7次能抑制三氯化铁诱导的大鼠动脉血栓形成(P<0.05),升高血小板内5-HT含量(P<0.05),抑制5-HT诱导的血小板聚集作用(P<0.05);在有无细胞外钙存在时,冰片血清均能够明显抑制5-HT诱导的血小板胞内[Ca2+]i升高。结论:冰片具有抗血栓作用,其机制可能与抑制血小板5HT释放和血小板聚集,抑制血小板胞浆[Ca2+]i升高有关。
Objective: To investigate the antithrombotic effect of borneol. Methods: Thrombus formation, platelet 5-hydroxytryptamine (5-HT) content, platelet aggregation rate and platelet intracellular free calcium concentration [Ca2 +] i were measured by thrombosis test, platelet aggregation test and platelet calcium concentration Impact. Results: ig ice corn oil solution 140 mg.kg-1, 7 times can inhibit the formation of arterial thrombosis induced by ferric chloride (P <0.05), increase the content of 5-HT (P <0.05), inhibit 5-HT induced platelet aggregation (P <0.05). In the presence of extracellular calcium, borneol significantly inhibited 5-HT-induced [Ca2 +] i elevation in platelets. CONCLUSION: Borneol has an antithrombotic effect. Its mechanism may be related to inhibition of platelet 5HT release and platelet aggregation, and inhibition of platelet cytoplasmic [Ca2 +] i elevation.