目的探讨肝素钙在治疗增生性肾炎中的作用。方法对 70例增生性肾小球肾炎患者 ,进行常规病理检查 ,以免疫组化方法测定其肾小球基质金属蛋白酶 (MMPs)———MMP 2、MMP 3的表达。随机分为常规疗法组 (A组 )和常规疗法 +肝素钙组 (B组 )。结果A组和B组系膜增生程度、球性硬化、节段性硬化、MMP 2、MMP 3无显著性差异。B组 10例血肌酐增高者治疗前后血清肌酐和内生肌酐清除率有显著性差异。B组的疗效优于A组。结论加用肝素钙治疗慢性肾炎有明显效果 Objective To investigate the role of heparin calcium in the treatment of proliferative glomerulonephritis. Methods 70 patients with proliferative glomerulonephritis were subjected to routine pathological examination. The expression of MMP 2, MMP 2 and MMP 3 was measured by immunohistochemistry. Randomly divided into conventional therapy group (A group) and conventional therapy + heparin group (B group). Results There was no significant difference between mesangial proliferative degree, sclerotic sclerosis, segmental sclerosis and MMP 2, MMP 3 in group A and group B. In group B, the serum creatinine and endogenous creatinine clearance rate of 10 patients with elevated serum creatinine before and after treatment were significantly different. The efficacy of group B is better than that of group A. Conclusion Heparin calcium treatment of chronic nephritis has a significant effect