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目的研究复方中药制剂毒素清对肺炎老龄大鼠的防治作用。方法复制大鼠大肠杆菌肺炎模型,分为青年及老龄对照组和模型组、毒素清高剂量、低剂量组及氟哌酸组。观察肺组织病理改变和肺组织含水量、肺泡灌洗液中性粒细胞计数和血清C-反应蛋白(CRP)、铜蓝蛋白(CP)。结果肺炎致肺组织损伤以老龄大鼠较青年大鼠严重;青年模型组和老龄模型组肺组织含水量、肺泡灌洗液中性粒细胞数、血清CRP及CP水平均高于青年对照组和老龄对照组;毒素清高、低剂量组肺组织病理改变和含水量增高明显改善,肺泡灌洗液中性粒细胞数、血清CRP及CP水平均低于老龄模型组。结论肺脏中性粒细胞和血清中急性反应蛋白参与肺炎的发生发展。毒素清对老龄大鼠肺炎的治疗作用明显,其机制与降低中性粒细胞数量和急性反应蛋白含量有关。
Objective To study the preventive and therapeutic effects of compound Chinese medicine preparation toxinqing on old pneumonia rats. Methods The rat E. coli pneumonia model was replicated and divided into young and old age control group and model group, toxin high dose, low dose group and norfloxacin group. Observe the pathological changes in lung tissue and lung water content, alveolar lavage fluid neutrophil count and serum C-reactive protein (CRP), ceruloplasmin (CP). Results The lung injury caused by pneumonia was severe in aged rats compared with young rats. The water content of lung, neutrophils in alveolar lavage fluid, serum CRP and CP levels were higher in the young model group and the old model group than in the young control group. The old age control group; toxin Qinggao, low dose group of lung pathological changes and increased water content significantly improved, alveolar lavage fluid neutrophils, serum CRP and CP levels were lower than the old model group. Conclusion Acute reactive protein in lung neutrophils and serum is involved in the development of pneumonia. Toxinqing has a significant therapeutic effect on pneumonia in aged rats. Its mechanism is related to the decrease of neutrophils and acute reactive protein content.