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1960年以前头颈部癌的治疗主要是手术及放射疗法,但其后化疗成为癌治疗体系的一个组成部分,动脉灌注化疗的开展,导致了新制癌剂的研究,使头颈部癌治疗体系及其预后产生了很大的变化。由于细胞生物学迅速的进展,根据细胞动力学,多剂并用疗法正在显示出卓越的效果。本文对头颈部癌的单剂化疗、多剂并用疗法、动脉灌注疗法及辅助化疗予以论述,并对头颈部癌化疗现状加以概述。【单剂化学疗法】对头颈部鳞状上皮癌有效的制癌剂有氨甲喋呤(MTX)和博莱霉素(BLM)。
The treatment of head and neck cancer before 1960 was mainly surgery and radiation therapy. However, subsequent chemotherapy became an integral part of the cancer treatment system. The development of arterial infusion chemotherapy led to the study of new carcinostatic agents and the treatment system for head and neck cancer. And its prognosis has changed a lot. Due to the rapid advancement of cell biology, multi-dose combination therapies are showing superior results based on cellular dynamics. This article discusses single-dose chemotherapy, multiple-dose combination therapy, arterial infusion therapy and adjuvant chemotherapy for head and neck cancer, and summarizes the status of chemotherapy for head and neck cancer. [Single dose chemotherapy] Effective carcinostatic agents for head and neck squamous epithelial cancer include methotrexate (MTX) and bleomycin (BLM).