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反应停是治疗Ⅱ型麻风反应的有效药物,近来国外有人用它治疗DLE、光化性痒疹等疾病,取得较好效果,国内则尚未见报告,且其疗效的作用机理尚不清楚,有些作者从免疫学角度进行了探讨,但未能取得一致的结论.本文在豚鼠和小白鼠身上进行了细胞免疫和体液兔疫的四项实验,从而对反应停的作用机理作了初步探讨,并在临床上观察治疗了17例DLE患者.一、动物实验1.反应停对小白鼠外周血中T淋巴细胞数目的影响(非特异性酯酶染色法):小白鼠共12只,分为两组,一组腹腔注射反应停每日150mg/kg,共半个月;另一组不给药,为对照组.用反应停前后两组小鼠均取血涂片,经非特异性酯酶染色,在油
Response to stop treatment is effective treatment of type II leprosy drug, some people use it recently to treat DLE, photochemical pruritus and other diseases, and achieved good results, the domestic has not been reported, and its mechanism of action is not yet clear, and some authors From immunological point of view, but failed to reach a consistent conclusion.In this paper, guinea pigs and mice were subjected to four experiments of cellular immunity and body fluids of rabies, and thus the mechanism of the reaction to stop made a preliminary study, and in The clinical observation and treatment of 17 cases of DLE patients.Animals experiment 1 reaction stop on the number of T lymphocytes in mice peripheral blood (non-specific esterase staining method): a total of 12 mice, divided into two groups, A group of intraperitoneal injection of 150mg / kg daily for a total of half a month; the other group is not administered as a control group before and after the reaction was stopped using two blood smears were stained by non-specific esterase in oil