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目的:研究米索前列醇内置阴道后穹窿不同剂量及不同间隔时间对中期妊娠的引产结局。方法:将150例拟行药物引产的中期妊娠孕妇随机分为观察组及对照组,每组75例,两组均采取米索前列醇内置阴道后穹窿引产,观察组每次用药间隔4 h,每次200μg,24 h最大剂量800μg;对照组每次用药间隔时间6 h,每次400,24 h最大剂量1 200μg;观察并对比两组孕妇引产结局。结果:两组孕妇引产成功率、阴道出血量比较均无统计学意义;观察组宫缩发动时间、总产程明显、用药剂量明显低于对照组(P<0.05),药物不良反应发生率比对照组显著降低(P<0.01)。结论:采取米索前列醇内置阴道后穹窿行中期妊娠引产时,每次200μg,间隔4 h给药,引产安全有效,适合临床推广。
Objective: To study misoprostol built-in vaginal fornix different doses and different intervals of labor induction of labor outcomes. Methods: One hundred and fifty pregnant women of mid-term pregnancy induced drug induced abortion were randomly divided into observation group and control group, with 75 cases in each group. Misoprostol was inserted into vaginal fornix after vaginal inoculation in each group. Each 200μg, 24 h maximum dose of 800μg; control group each time interval of 6h, 400,24 h maximum dose of 1 200μg; observed and compared two groups of pregnant women induction of labor. Results: The success rate of induced labor and vaginal bleeding in both groups were not statistically significant. The time of uterine contractions in the observation group was significantly shorter than that in the control group (P <0.05), and the incidence of ADR was higher than that of the control group Group was significantly lower (P <0.01). Conclusion: Taking misoprostol with vaginal posterior fornix for mid-term pregnancy induced abortion, each time 200μg, 4 h intervals, induction of labor is safe and effective, suitable for clinical promotion.