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(www.colorcon.com.cn)1目的本研究的目的旨在评估一个开发中的、低黏度的水性薄膜包衣系统在新型的半连续式包衣机中的快速应用。Consi Gma(GEA制药系统)包衣机是连续的固体颗粒口服剂制造工艺中的最终操作步骤。该包衣机采用迫使片剂瀑布式运动的设计,比传统的包衣锅实现了更大的包衣液利用率,包衣效率更高。2方法2.1材料采用250 mg的圆形空白片剂作为包衣片芯。该包衣系统是卡乐康公司创新开发的基于Kollicoat
(www.colorcon.com.cn) 1 Purpose The purpose of this study was to evaluate the rapid application of a developing, low viscosity aqueous film coating system in a new semi-continuous coating machine. Consi Gma (GEA Pharmaceutical Systems) The coating machine is the final step in the continuous solid particle oral dosage manufacturing process. The coater, which is designed to force the tablet to fall in motion, achieves greater coating fluid utilization than the conventional coating pan and provides greater coating efficiency. 2 Methods 2.1 Materials 250 mg round blank tablets were used as coated cores. The coating system is Kolkata developed based on Kollicoat