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A new 4,5-diaryl-1H-imidazole was synthesized and characterized by 1H NMR, ESI-MS, elemental analysis and FT-IR. The crystal structure of the title compound(C19H16Cl2N2O2, Mr = 375.24) has been determined by single-crystal X-ray diffraction. Crystal parameters: monoclinic system, space group P21/n, a = 14.349(3), b = 8.7918(18), c = 15.352(3) , β = 108.56(3)°, V = 1836.1(6) 3, Z = 4, F(000) = 776, Dc = 1.357 g/cm3, μ = 0.368 mm-1, the final R = 0.0502 and wR = 0.1066 for 2324 observed reflections with I > 2σ(I). A total of 16117 reflections were collected, of which 3615 were independent(Rint = 0.0595). The preliminary bioassay suggested that the title compound exhibits distinct effective inhibition on the proliferation of cancer cell lines.
A new 4,5-diaryl-1H-imidazole was synthesized and characterized by 1H NMR, ESI-MS, elemental analysis and FT-IR. The crystal structure of the title compound (C19H16Cl2N2O2, Mr = 375.24) a = 14.349 (3), b = 8.7918 (18), c = 15.352 (3) , β = 108.56 (3) °, V = D = 1.357 g / cm3, μ = 0.368 mm-1, the final R = 0.0502 and wR = 0.1066 for 2324 observed reflections with I> 2σ (1836.1) 3 Z = 4 F 000 = 776 Dc = I). A total of 16117 reflections were collected, of which 3615 were independent (Rint = 0.0595). The preliminary bioassay suggested that the title compound exhibits distinct effective inhibition on the proliferation of cancer cell lines.