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目的通过建立豚鼠过敏性哮喘模型,观察固本清肺贴膏对豚鼠哮喘模型的平喘、抗炎作用。方法采用腹腔注射10%卵蛋白生理盐水致敏,14d后用1%卵蛋白生理盐水激发3次,建立豚鼠过敏性哮喘模型,观察固本清肺贴膏对哮喘豚鼠的引喘潜伏期及支气管肺泡灌洗液中白细胞总数的影响。结果固本清肺贴膏能延长哮喘豚鼠引喘潜伏期、减少哮喘豚鼠支气管肺泡灌洗液中白细胞总数。结论固本清肺贴膏对豚鼠过敏性哮喘模型具有平喘和抗炎作用。
Objective To establish an allergic asthma model in guinea pigs to observe the antiasthmatic and anti-inflammatory effects of Guben Qingfei Paste on guinea pig asthma model. Methods The model of allergic asthma was established by intraperitoneal injection of 10% ovalbumin in normal saline and challenged with 1% ovalbumin saline for 3 days after 14 days. The latency of asthma in Guinea pigs and the latent period of bronchial alveoli Effect of total leukocyte count in lavage fluid. Results Guben Qingfei Paste can prolong the latent period of asthma in asthmatic guinea pigs and reduce the total number of leukocytes in bronchoalveolar lavage fluid of asthmatic guinea pigs. Conclusion Guben Qingfei plaster has antiasthmatic and anti-inflammatory effects on the model of allergic asthma in guinea pigs.